Ivabradine Population PK Simulator

Number of Subjects:

Dose (mg):

Dosing Schedule:

Number of Doses (if BID):

Body Weight (kg):

Female (%):

Clearance (L/h):

Central Volume (L):

Inter-compartmental Clearance (L/h):

Peripheral Volume (L):

Absorption Rate Constant (1/h):

Bioavailability:

CL:

V1:

Ka:

Simulation Time (hours):

Y-Axis Scale:

Model: Two-compartment with first-order absorption | Covariates: Body weight on CL and V (allometric scaling)

Expected values for 7.5 mg dose: Cmax ~20-30 ng/mL | Tmax ~1 h | t½ ~6 h | Based on published ivabradine PK studies